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Huntington's Disease: Les Jeux Sont Faits?
Edith L Pfister1, Neil Aronin2
1Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Trends in Molecular Medicine
|September 7, 2020
Summary
Aberrant neurodevelopment occurs in Huntington
Area of Science:
- Neuroscience and Developmental Biology
Background:
- Huntington's disease (HD) is a progressive neurodegenerative disorder.
- Aberrant neurodevelopment is increasingly recognized as a factor in HD pathogenesis.
Purpose of the Study:
- To explore the implications of prenatal pathological changes in Huntington's disease.
- To relate these early changes to disease onset, progression, and therapeutic strategies.
Main Methods:
- Review and synthesis of existing research on neurodevelopmental alterations in HD models.
- Analysis of pathological changes occurring during prenatal development.
Main Results:
- Evidence suggests neurodevelopmental abnormalities are present in both human Huntington's disease and relevant animal models.
- Prenatal pathological changes may significantly influence the clinical manifestation of HD.
Conclusions:
- Understanding prenatal pathology is crucial for developing effective Huntington's disease therapies.
- Early-stage interventions targeting neurodevelopment could modify disease trajectory.
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