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Updated: Dec 9, 2025
05:46
Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
Published on: May 27, 2022
6.6K
Extraction of naturally occurring cannabinoids: an update
Lutfun Nahar1, Shaikh Jamal Uddin2, Md Ashraful Alam3
1Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Olomouc, Czech Republic.
Phytochemical Analysis : PCA
|September 7, 2020
Summary
This review summarizes methods for extracting cannabinoids, compounds interacting with cannabinoid receptors. Key factors influencing extraction yield include temperature, time, pressure, and solvent polarity for optimal cannabinoid analysis.
Area of Science:
- Pharmacology
- Analytical Chemistry
Background:
- Cannabinoids are organic molecules interacting with cannabinoid receptors, exhibiting properties similar to Cannabis sativa L. compounds.
- Extraction from various matrices is a crucial preliminary step for cannabinoid analysis.
Purpose of the Study:
- To conduct a comprehensive literature review on extraction methods and protocols for naturally occurring cannabinoids.
Main Methods:
- Extensive literature search across Web of Knowledge, PubMed, and Google Scholar.
- Keywords included 'cannabinoids', 'extraction', 'Cannabis', 'hemp', 'marijuana', and 'Cannabis sativa'.
Main Results:
- Common methods for plant materials include maceration, Soxhlet, supercritical fluid, ultrasound-assisted, and microwave-assisted extraction.
- Solid-phase extraction and liquid-liquid extraction are used for biological samples, food, beverages, and wastewater.
- Extraction parameters can be optimized using mathematical modeling; at least six US patents exist for cannabinoid extraction.
Conclusions:
- Extraction temperature, time, and pressure are critical for overall yield.
- Solvent polarity is an important consideration for specific extraction techniques.
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