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Glyphosate-induced Delayed Pyloric Obstruction, Ulcer and Scar Changes
Jin Yong Hao1, Tao Jiang1, Xiao Jun Huang1
1Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|September 7, 2020
Summary
Acute glyphosate poisoning can lead to delayed upper gastrointestinal issues, including pyloric obstruction and gastric ulcers. Early management and long-term therapies are crucial for gastric mucosa repair.
Area of Science:
- Toxicology
- Gastroenterology
Background:
- Glyphosate is a prevalent herbicide with frequent accidental poisonings.
- Acute glyphosate exposure primarily causes gastrointestinal distress.
Observation:
- A patient accidentally ingested glyphosate, experiencing acute nausea and vomiting.
- Two months post-ingestion, the patient developed upper gastrointestinal obstruction.
- Endoscopy revealed esophageal normality but showed gastric scarring, pyloric obstruction, and an active gastric ulcer.
Findings:
- Delayed gastric ulceration and pyloric obstruction following acute glyphosate ingestion.
- Absence of acute gastrointestinal bleeding or perforation in the initial phase.
Implications:
- Gastric lavage techniques and avoiding acid-base neutralization are critical.
- Sustained acid suppression and mucosal protection are vital for gastric healing.
- This case highlights the potential for severe, delayed gastrointestinal complications from glyphosate exposure.
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