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Published on: June 10, 2021
Rh(III)-Catalyzed Dual C-H Functionalization/Cyclization Cascade by a Removable Directing Group: A Method for
Zhihao Shu1,2, Jianhui Zhou2, Junyou Li2,3
1School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Abstract:
An interesting Rh(III)-catalyzed dual C-H functionalization/cyclization cascade of azomethine imine with diazophosphonate by a removable directing group for the synthesis of highly fused pyrano[de]isochromene has been achieved. The transformation shows that the desired pyrano[de]isochromenes with two oxygen atoms on its core scaffold could be constructed with good to excellent yields (up to 86%) via a facile one-pot, multiple-step cascade reaction, along with broad generality and versatility.
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