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Standardized herbal extract PM014 alleviates fine dust-induced lung inflammation in mice
Ye-Seul Lee1, Daeun Min2, Seon-Young Park2
1Department of Anatomy and Acupoint, College of Korean Medicine, Gachon University, Seongnam, 13120, South Korea.
Background:
Fine dust penetrates deep into the human alveoli, and the fine dust accumulated in the bronchus and lungs can directly trigger various respiratory diseases. PM014 (HL301) is the herbal extract derived from the herbal medicine Chung-Sang-Bo-Ha-Tang which is used for the treatment of lung diseases.
Methods:
To evaluate the effect of PM014 on the lung inflammation induced by fine dust, this study investigated inflammatory responses in the lung upon pm10 exposure by examining the infiltration of inflammatory cell profiles from bronchial alveolar lavage fluid (BALF), lung histology, and production of pro-inflammatory cytokines measured by RT-PCR and ELISA.
Results:
PM014-treated mice exhibited reduced lung tissue damage and inflammatory cell infiltration. Bronchoalveolar lavage fluid (BALF) analysis showed significant decrease in the population of total cells, macrophages, eosinophils, and neutrophils in PM014-treated mice. PM014 treatment downregulated the pro-inflammatory cytokine expressions including IL-1b, IL-8, IL-6, TNF-alpha, IL-21 and IL-17. ELISA analysis also showed reduced production of IL-1b, IL-6 and IL-17 in PM014-treated mice.
Conclusion:
PM014 suppressed the pm10-induced inflammatory response in mice. This study shows that PM014 is a possible therapeutic agent for lung inflammation induced by fine dust.
Insights
PM014, a herbal extract, effectively reduced lung inflammation and tissue damage caused by fine dust exposure in mice. This natural compound shows promise for treating respiratory diseases linked to air pollution.
Area of Science:
- Pharmacology
- Toxicology
- Herbal Medicine
Background:
- Fine dust inhalation leads to respiratory diseases by accumulating in the lungs.
- PM014 is a herbal extract from Chung-Sang-Bo-Ha-Tang, traditionally used for lung conditions.
Purpose of the Study:
- To evaluate the efficacy of PM014 in mitigating lung inflammation induced by fine dust (PM10).
Main Methods:
- Investigated inflammatory responses in mice exposed to PM10.
- Assessed inflammatory cell infiltration in bronchoalveolar lavage fluid (BALF).
- Analyzed lung histology and pro-inflammatory cytokine levels (RT-PCR, ELISA).
Main Results:
- PM014 treatment significantly reduced lung tissue damage and inflammatory cell infiltration.
- BALF analysis showed decreased total cells, macrophages, eosinophils, and neutrophils.
- PM014 downregulated key pro-inflammatory cytokines (IL-1b, IL-8, IL-6, TNF-alpha, IL-21, IL-17).
Conclusions:
- PM014 effectively suppressed PM10-induced lung inflammation in a mouse model.
- PM014 demonstrates potential as a therapeutic agent for fine dust-induced lung inflammation.
