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Related Experiment Video

Updated: Jun 18, 2026

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

Neutrophils and host defense.

R I Lehrer¹, T Ganz, M E Selsted

¹Department of Medicine, UCLA School of Medicine.

Annals of Internal Medicine

|July 15, 1988

Summary

Neutrophil dysfunction underlies frequent infections, impacting host defense. Understanding neutrophil receptors, oxidant production, and antimicrobial components aids clinical evaluation of immune disorders.

Area of Science:

Immunology
Cell Biology
Clinical Medicine

Background:

Neutrophils are primary phagocytes crucial for early infection response.
Neutropenia and neutrophil dysfunction are linked to increased infection susceptibility.
Recent research elucidates molecular underpinnings of neutrophil disorders.

Purpose of the Study:

To review neutrophil function in host defense.
To connect molecular pathology to clinical syndromes of frequent infections.
To guide physicians in evaluating patients with recurrent or unusual infections.

Main Methods:

Review of advances in neutrophil receptor function (recognition, movement, adhesion).
Analysis of chronic granulomatous disease pathogenesis for insights into oxidant production.

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Published on: February 6, 2020

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Last Updated: Jun 18, 2026

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Detecting Migration and Infiltration of Neutrophils in Mice

Detecting Migration and Infiltration of Neutrophils in Mice

Published on: February 6, 2020

Identification and characterization of neutrophil antimicrobial components, including defensins.

Main Results:

Defined roles of neutrophil receptors in cellular processes.
Elucidated enzymatic machinery for antimicrobial oxidant production.
Characterized natural antibiotics like defensins and their role in host defense.

Conclusions:

Understanding neutrophil molecular pathology is key to diagnosing immune dysfunction.
Knowledge of neutrophil function aids clinical assessment of frequent infections.
This review provides a clinical context for evaluating patients with neutrophil-related disorders.