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Otoprotective Effect of Cortexin, Cogitum, and Elkar Administered Simultaneously with Netromycin in the Experiment
I N D'yakonova1, Yu S Ishanova2, I V Rakhmanova3
1Department of Physiology, Medical-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia.
Abstract:
We studied possible otoprotective effect of drugs widely used for the correction of perinatal hypoxic brain damage in premature infants. The experiments were carried out on immature rabbits with an immature hearing organ. The auditory function was assessed by DPOAE and ABR methods in intact animals and rabbits treated with therapeutic doses of netromycin alone or in combination with the drugs that normalize metabolic processes in the brain (Cortexin, Cogitum, Elkar, vitamin B2, ATP, and cocarboxylase). It was found that the administered drugs produced an otoprotective effect and reduced the severity, but did not eliminate the ototoxic effect.
Insights
Certain drugs used for perinatal hypoxic brain damage show otoprotective effects in premature infants. These medications reduced, but did not fully prevent, hearing damage caused by netromycin in immature rabbits.
Area of Science:
- Otolaryngology
- Neonatology
- Pharmacology
Background:
- Premature infants are at risk of hypoxic brain damage.
- Drugs used for perinatal hypoxic brain damage correction may have unintended ototoxic effects.
- Understanding potential otoprotective effects is crucial for infant health.
Purpose of the Study:
- To investigate the otoprotective potential of drugs commonly used for perinatal hypoxic brain damage.
- To assess if these drugs can mitigate ototoxicity induced by netromycin in a preclinical model.
Main Methods:
- Experiments conducted on immature rabbits simulating premature infant conditions.
- Auditory function assessed using Distortion Product Otoacoustic Emissions (DPOAE) and Auditory Brainstem Response (ABR) methods.
- Comparison between intact animals, netromycin-treated animals, and animals treated with netromycin in combination with metabolic drugs.
Main Results:
- Netromycin administration led to ototoxic effects on auditory function.
- Co-administration of drugs like Cortexin, Cogitum, Elkar, vitamin B2, ATP, and cocarboxylase demonstrated an otoprotective effect.
- These drugs significantly reduced the severity of ototoxicity but did not completely eliminate it.
Conclusions:
- Drugs used for perinatal hypoxic brain damage correction possess a degree of otoprotection against netromycin-induced ototoxicity.
- Further research is warranted to optimize therapeutic strategies and fully prevent hearing loss in vulnerable infants.
- The findings suggest a potential benefit in combining these metabolic drugs with aminoglycosides in specific clinical scenarios.
