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The Influence of the Cholesterol Level in Cells on Endovanilloid Cytotoxicity
M G Akimov1, P V Dudina2, A M Gamisonia2
1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. akimovmike@gmail.com.
Doklady. Biochemistry and Biophysics
|September 7, 2020
Abstract:
The influence of the cellular cholesterol content on the cytotoxicity of endovanilloids acyldopamines was studied in MDA-MB-231 and MCF 10A cells. The activity of acyldopamines depends on the cellular cholesterol content, and a decrease in cholesterol content increases the cytotoxicity of acyldopamines.
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