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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
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Introduction: Druggable Lipid Signaling Pathways.

Yasuyuki Kihara1

  • 1Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. kihara-yasuyuki@umin.net.

Advances in Experimental Medicine and Biology
|September 7, 2020
PubMed
Summary

This review explores druggable lipid signaling pathways and their therapeutic potential. It highlights current drugs targeting lipid metabolism and function, offering insights into future drug discovery for various diseases.

Keywords:
BiochemistryDrug discoveryLipid mediatorMolecular biologyPharmacology

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Area of Science:

  • Lipid biology and pharmacology.
  • Drug discovery and development.
  • Molecular signaling pathways.

Background:

  • Lipids are vital molecules involved in energy storage, cellular structure, and signaling.
  • Numerous drugs targeting lipid metabolism and function have been developed for disease treatment.
  • Recent advances include sphingosine 1-phosphate receptor modulators for multiple sclerosis.

Purpose of the Study:

  • To review current drugs targeting lipid signaling pathways.
  • To outline future directions for drug discovery in lipid biology.
  • To provide a comprehensive overview of druggable lipid signaling pathways and proteins.

Main Methods:

  • Literature review of existing research on lipid signaling pathways and drug targets.
  • Analysis of approved drugs and their mechanisms of action.
  • Identification of key lipid signaling pathways and proteins for therapeutic intervention.

Main Results:

  • Summarizes 9 reviews on currently available drugs targeting lipid signaling pathways.
  • Covers diverse lipid signaling pathways including prostanoids, leukotrienes, sphingolipids, and endocannabinoids.
  • Includes lipid signaling proteins such as phosphoinositide 3-kinase and G protein-coupled receptors.

Conclusions:

  • Drugs targeting lipid signaling pathways hold significant promise for future human health.
  • Continued research in this area is crucial for developing innovative therapies.
  • The review series serves as a valuable resource for understanding druggable lipid targets.