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Updated: Dec 9, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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MiR-155 affects renal carcinoma cell proliferation, invasion and apoptosis through regulating GSK-3β/β-catenin

R-J Wei1, C-H Zhang, W-Z Yang

  • 1Department of Urology Surgery, The First Central Hospital of Baoding, Baoding, Hebei, China.

European Review for Medical and Pharmacological Sciences
|September 7, 2020
PubMed

Insights

This article has been withdrawn due to suspected research misconduct. The publisher retracted the study on miR-155's role in renal carcinoma after authors failed to verify data originality.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The study investigated the role of microRNA-155 (miR-155) in renal carcinoma.
  • It aimed to elucidate the regulatory mechanisms involving GSK-3β/β-catenin signaling.

Purpose of the Study:

  • To determine how miR-155 influences renal carcinoma cell proliferation, invasion, and apoptosis.
  • To explore the involvement of the GSK-3β/β-catenin pathway in these processes.

Main Methods:

  • The study likely involved cell culture experiments with renal carcinoma cells.
  • Investigated the expression levels of miR-155, GSK-3β, and β-catenin.
  • Assessed cell proliferation, invasion, and apoptosis assays.

Main Results:

  • The article, "MiR-155 affects renal carcinoma cell proliferation, invasion and apoptosis through regulating GSK-3β/β-catenin signaling pathway," has been withdrawn.
  • The withdrawal is due to suspected research misconduct, with authors failing to prove data originality.

Conclusions:

  • Due to the withdrawal, no conclusions can be drawn from the original study.
  • The scientific community cannot rely on the findings presented in the withdrawn article.

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