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Updated: Dec 9, 2025
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Direct incorporation of [18F] into Aliphatic Systems: A promising Mn-catalysed Labelling Technique for PET Imaging
Sara Cesarec1, Jonathan A Robson1, Laurence S Carroll1
1Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom.
Background:
One of the challenges in positron emission tomography (PET) is labelling complex aliphatic molecules.
Objective:
This study aimed to develop a method of metal-catalysed radiofluorination that is site-selective and works in moderate to good yields under facile conditions.
Methods:
Herein, we report on the optimisation of an aliphatic C-H to C-18F bond transformation catalysed by a Mn(porphyrin) complex.
Results:
The successful oxidation of 11 aliphatic molecules, including progesterone, is reported. Radiochemical Incorporations (RCIs) up to 69% were achieved within 60 min without the need for pre-activation or special equipment.
Conclusion:
The method features mild conditions (60 °C) and promises to constitute a valuable approach to labelling of biomolecules and drug substances.
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