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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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[Thromboelastography-based assessment of coagulation function in patients with chronic kidney disease and the risk

Sixian Wu1, Hao Yuan1, Yifeng Zhou2

  • 1Clinical Laboratory, First Affiliated Hospital of Hunan Normal University/Hunan Provincial People's Hospital, Changsha 410005, China.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|September 8, 2020
PubMed

Insights

Chronic kidney disease (CKD) patients show worsening hypercoagulation with disease progression. Reduced estimated glomerular filtration rate (eGFR), higher platelet count, and hemoglobin levels are key risk factors for this hypercoagulable state.

Area of Science:

  • Nephrology
  • Hematology
  • Clinical Pathology

Background:

  • Chronic kidney disease (CKD) is associated with altered coagulation.
  • Thromboelastography (TEG) offers a comprehensive assessment of coagulation.
  • Understanding hypercoagulation in CKD is crucial for managing thrombotic risks.

Purpose of the Study:

  • To evaluate coagulation profile changes in CKD patients using TEG.
  • To identify risk factors contributing to hypercoagulation in CKD.

Main Methods:

  • 128 CKD patients and 21 healthy controls were analyzed.
  • Conventional coagulation tests and TEG were performed.
  • CKD patients were categorized into hypercoagulation (MA > 68 mm) and non-hypercoagulation groups.

Main Results:

  • CKD patients exhibited elevated fibrinogen and D-Dimer levels.
  • TEG revealed decreased reaction time and K time, with increased MA and α-angle in CKD patients.
  • Independent risk factors for hypercoagulability included lower eGFR, higher platelet count, and elevated hemoglobin levels.

Conclusions:

  • Hypercoagulable state in CKD intensifies with disease progression.
  • Reduced eGFR, increased platelet count, and hemoglobin levels are significant risk factors for hypercoagulability in CKD.
Abstract

Keywords:
chronic kidney diseasehypercoagulabilitymaximal amplituderisk factorsthromboelastography

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