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[Relationship between circadian rhythm related brain dysfunction and bipolar disorder]
Manli Liu1, Yajing Meng1, Wei Wei1
1Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China.
Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|September 8, 2020
Summary
Bipolar disorder patients show altered functional connectivity (FC) in the suprachiasmatic nucleus (SCN). This brain region
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Bipolar disorder (BD) is a complex mental health condition.
- The suprachiasmatic nucleus (SCN) regulates biological rhythms.
- Disruptions in biological rhythms are implicated in BD.
Purpose of the Study:
- To investigate functional connectivity (FC) changes in the SCN of BD patients.
- To cluster BD patients based on SCN FC patterns.
Main Methods:
- Recruited 138 BD patients and 150 healthy controls.
- Utilized resting-state functional magnetic resonance imaging (fMRI).
- Applied DPARSF software for SCN FC analysis and k-means for clustering.
Main Results:
- BD patients exhibited enhanced FC between the SCN and paraventricular nucleus.
- BD patients showed increased FC between the SCN and dorsomedial hypothalamus nucleus.
- K-means clustering identified two distinct subtypes of BD based on SCN FC.
Conclusions:
- Functional connectivity alterations in the SCN are present in BD.
- SCN FC patterns can differentiate BD into subtypes.
- Biological rhythm pathways may serve as potential biomarkers for BD.
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