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Hypothermia and blood pH. A review
1Surgery Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
Archives of Internal Medicine
|July 1, 1988
Summary
Managing hypothermia involves understanding its complications like acidosis and impaired function. This review explores how managing blood pH during hypothermia may reduce these harmful effects.
Area of Science:
- Medical Science
- Physiology
- Critical Care Medicine
Background:
- Hypothermia is frequently managed in emergency, operating, and intensive care units.
- Therapeutic hypothermia is used in cardiac surgery to decrease metabolism and oxygen needs during ischemia.
- Hypothermia presents complications including acidosis, myocardial dysfunction, and organ impairment.
Purpose of the Study:
- To review evidence on the impact of blood pH management in hypothermic patients.
- To explore how pH modulation affects hypothermia-induced complications.
- To provide a summary of laboratory, theoretical, and clinical findings.
Main Methods:
- Literature review synthesizing laboratory, theoretical, and clinical data.
- Analysis of studies investigating blood pH management during hypothermia.
- Examination of the relationship between pH and hypothermia's adverse effects.
Main Results:
- Evidence suggests pH management can influence the severity of hypothermia complications.
- Specific pH targets may mitigate acidosis and improve organ function.
- Altering blood pH could modify myocardial and clotting disturbances.
Conclusions:
- Blood pH management is a critical consideration in treating hypothermic patients.
- Optimizing pH may reduce the incidence or magnitude of deleterious effects.
- Further clinical research is warranted to establish definitive pH management protocols.