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Lipopolysaccharide binding protein is associated with CVD risk in older adults
Lisa M Roberts1,2, Thomas W Buford3,4,5
1Department of Medicine, Division of Gerontology/Geriatrics/Palliative Care, University of Alabama At Birmingham, 1313 13th Street S., Birmingham, AL, USA.
Insights
Higher levels of lipopolysaccharide binding protein (LBP) are linked to lower cardiovascular disease (CVD) risk in older adults. This suggests LBP may play a role in mitigating CVD risk factors.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Microbiome Research
Background:
- Gut permeability is a potential contributor to cardiovascular disease (CVD) risk.
- Biomarkers for gut permeability and their association with CVD risk, especially in older adults, are not well-established.
Purpose of the Study:
- To investigate the association between serum biomarkers of gut permeability and bacterial toxin clearance and CVD risk in older adults.
- Specifically examined intestinal fatty acid-binding protein (iFABP), cluster of differentiation 14 (CD14), and lipopolysaccharide binding protein (LBP).
Main Methods:
- Cross-sectional study of 74 older adults (mean age 69.6 years) stratified by CVD risk.
- One-way ANOVAs and Pearson correlations were used to analyze biomarker differences and associations with CVD risk scores.
Main Results:
- Lipopolysaccharide binding protein (LBP) levels differed significantly across CVD risk categories, being higher in moderate and high-moderate risk groups compared to the high-risk group.
- LBP showed a moderate negative correlation with age and systolic blood pressure, and a small positive correlation with total and LDL cholesterol.
- Intestinal fatty acid-binding protein (iFABP) and cluster of differentiation 14 (CD14) did not show significant differences between risk categories.
Conclusions:
- Higher circulating LBP concentrations are associated with lower CVD risk in older adults.
- Lower iFABP and reduced systemic inflammation were also linked to lower CVD risk.
- These findings suggest LBP may be a significant factor in reducing CVD risk among the elderly.
Background:
Intestinal (i.e., "gut") permeability may be related to cardiovascular disease (CVD) risk, but biomarkers for gut permeability are limited and associations with CVD risk are unknown-particularly among older adults.
Aims:
This cross-sectional study aimed to determine if serum biomarkers related to gut permeability [intestinal fatty acid-binding protein (iFABP)] and bacterial toxin clearing [cluster of differentiation 14 (CD14), lipopolysaccharide binding protein (LBP)] are associated with CVD risk among older adults.
Methods:
Older adults (n = 74, 69.6 ± 6.5-years-old) were stratified by CVD risk category. One-way ANOVAs determined differences in each biomarker by risk category, and associations with risk score were evaluated with Pearson correlations.
Results:
LBP (p = 0.007), but not iFABP and CD14, was significantly different between CVD risk categories. Post-hoc tests indicated LBP was higher in moderate risk and high-moderate risk compared to the high risk category (p < 0.005). Evaluation of LBP and individual components in the risk score demonstrated a moderate, negative correlation of LBP with age and systolic blood pressure (r = - 0.335 and r = - 0.297) and a small positive correlation between LBP and total cholesterol and LDL cholesterol (r = 0.204 and r = 0.220).
Discussion/Conclusion:
Lower risk for CVD was associated with higher circulating concentrations of LBP, lower iFABP, and lower systemic inflammation in older adults. Further, there were small positive relationships between total and LDL cholesterol and circulating levels of LBP. These data suggest LBP may be a key component in reducing CVD risk in older adults.
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