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The ABL oncogene in human leukemias.
1Department of Medicine, University of Chicago, Illinois 60637.
Blood Reviews
|March 1, 1988
Summary
The Philadelphia chromosome activates the ABL proto-oncogene, forming BCR-ABL fusion proteins with enhanced tyrosine kinase activity. This discovery aids in diagnosing and managing chronic myelogenous leukemia.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The ABL proto-oncogene is activated by translocation, forming a fusion gene similar to viral activation.
- This BCR-ABL fusion protein exhibits enhanced tyrosine kinase activity.
Purpose of the Study:
- To investigate the role of ABL proto-oncogene activation in leukemia.
- To explore the diagnostic and therapeutic implications of BCR-ABL fusion genes.
Main Methods:
- Analysis of the ABL proto-oncogene and its translocation products.
- Development of molecular probes for diagnostic applications.
Main Results:
- BCR-ABL fusion gene formation leads to enhanced tyrosine kinase activity.
- Molecular probes are crucial for diagnosing and managing chronic myelogenous leukemia.
- A new ABL species is identified in acute lymphoblastic leukemia, likely a fusion protein.
Conclusions:
- ABL activation via the Philadelphia chromosome is key in certain leukemias.
- BCR-ABL fusion proteins are significant in chronic myelogenous leukemia and potentially acute lymphoblastic leukemia.
- Further research, including molecular cloning, is needed to confirm fusion gene products in all cases.