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A Dynamic Data Correction Method for Enhancing Resolving Power of Integrated Spectra in Spectroscopic Analysis
Chih-Hao Hsiao1, Yin-Hung Lai1,2, Shu-Yun Kuo1
1Genomics Research Center, Academia Sinica, No. 128 Academia Road, Section 2, Taipei 11529, Taiwan (ROC).
Abstract:
A dynamic data correction method embedded in the process of data acquisition improves spectral quality. The method minimizes the impact of random errors in spectroscopic measurements by correcting peak positions in every single-scan spectrum. The method is fast enough to facilitate online data correction. The integration of corrected spectra improves resolving power and signal-to-noise ratio. The correction method can apply to most analytical spectra. In mass spectrometry and Raman spectroscopy, observations show that it improved the average resolving power by roughly 40-150% and revealed unresolved spectral features.
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