Related Experiment Video
Updated: Dec 9, 2025
07:40
Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
Published on: October 25, 2019
6.3K
Host cell death during infection with Chlamydia: a double-edged sword
1The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden.
FEMS Microbiology Reviews
|September 8, 2020
Summary
Chlamydiae bacteria manipulate host cell death for survival and replication. Understanding these virulence strategies is crucial for developing new treatments against chlamydial infections.
Area of Science:
- Microbiology
- Cell Biology
- Pathogenesis
Background:
- Chlamydiae are obligate intracellular bacteria with diverse hosts.
- Chlamydia trachomatis causes blindness and sexually transmitted diseases.
- Host cell death is integral to the chlamydial infection cycle.
Purpose of the Study:
- To review current knowledge on Chlamydia's modulation of host cell death.
- To identify knowledge gaps and future research directions.
- To explore potential therapeutic strategies based on virulence mechanisms.
Main Methods:
- Review of existing literature on Chlamydia spp. and host cell death.
- Analysis of genetic tools for Chlamydia modification.
- Integration of cell biology and immunology findings.
Main Results:
- Chlamydiae employ versatile strategies to control host cell survival and death.
- Recent advances challenge previous assumptions about chlamydial virulence.
- Connections between regulated cell death and cell-intrinsic immunity are highlighted.
Conclusions:
- Further research is needed to fully understand Chlamydia's virulence.
- Investigating host cell death modulation may reveal novel therapeutic targets.
- This knowledge can lead to improved treatments for chlamydial diseases.
Keywords:
bacterial exitbacterial toxicitycell-autonomous immunityintracellular bacteriaregulated cell deathvirulence strategiesMore Related Videos
Related Concept Videos
01:29Bacterial Phylum Chlamydiae
312
The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
312
01:17Phagocytosis of Apoptotic Cells
4.5K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
4.5K
01:40Cell-mediated Immune Responses
82.3K
Overview
82.3K
01:30Overview of Cell Death
8.8K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
8.8K
01:28Cells of the Innate Immune Response
8.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.2K
01:26Sexually Transmitted Infections
693
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
693