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Trace Elements in the Large Population-Based HUNT3 Survey
Tore Syversen1, Lars Evje2,3, Susann Wolf2,4
1Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, N-7491, Trondheim, Norway. toresyv@gmail.com.
Biological Trace Element Research
|September 8, 2020
Summary
This study analyzed trace elements in blood samples from the HUNT3 population. Results suggest using at least 0.5 mL of blood for future multielement analysis to detect more non-essential elements.
Area of Science:
- Environmental Health
- Analytical Chemistry
- Public Health
Background:
- The Nord-Trøndelag Health Study (HUNT Study) is a major Norwegian population health survey conducted in ~10-year intervals.
- The HUNT3 survey (2006-2008) collected 28,000 samples for trace element analysis.
Purpose of the Study:
- Determine the minimum blood volume for trace element analysis.
- Compare results with previous surveys in healthy populations.
- Assess essential and non-essential trace element levels.
Main Methods:
- Selected 758 healthy individuals from HUNT3 without occupational exposure.
- Performed multielement analysis on small blood samples (0.25 mL) using ICP-MS.
- Digested samples to determine concentrations of selected trace elements.
Main Results:
- Reported concentrations for essential (B, Co, Cu, Mn, Se, Zn) and non-essential elements (e.g., As, Cd, Pb, Hg, Ni).
- Results align with previous HUNT3 findings and recent international studies.
- Several non-essential element concentrations were below the limit of detection with 0.25 mL samples.
Conclusions:
- The analytical procedure using 0.25 mL blood is comparable to previous studies.
- A minimum of 0.5 mL blood is recommended for future large-scale trace element analysis using similar ICP-MS methods.
- This ensures detection of a wider range of non-essential elements.
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