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Trace Elements in the Large Population-Based HUNT3 Survey.

Tore Syversen1, Lars Evje2,3, Susann Wolf2,4

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Biological Trace Element Research
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Summary
This summary is machine-generated.

This study analyzed trace elements in blood samples from the HUNT3 population. Results suggest using at least 0.5 mL of blood for future multielement analysis to detect more non-essential elements.

Keywords:
Blood samplesICP-MS analysisPopulation-based studyTrace elements

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Area of Science:

  • Environmental Health
  • Analytical Chemistry
  • Public Health

Background:

  • The Nord-Trøndelag Health Study (HUNT Study) is a major Norwegian population health survey conducted in ~10-year intervals.
  • The HUNT3 survey (2006-2008) collected 28,000 samples for trace element analysis.

Purpose of the Study:

  • Determine the minimum blood volume for trace element analysis.
  • Compare results with previous surveys in healthy populations.
  • Assess essential and non-essential trace element levels.

Main Methods:

  • Selected 758 healthy individuals from HUNT3 without occupational exposure.
  • Performed multielement analysis on small blood samples (0.25 mL) using ICP-MS.
  • Digested samples to determine concentrations of selected trace elements.

Main Results:

  • Reported concentrations for essential (B, Co, Cu, Mn, Se, Zn) and non-essential elements (e.g., As, Cd, Pb, Hg, Ni).
  • Results align with previous HUNT3 findings and recent international studies.
  • Several non-essential element concentrations were below the limit of detection with 0.25 mL samples.

Conclusions:

  • The analytical procedure using 0.25 mL blood is comparable to previous studies.
  • A minimum of 0.5 mL blood is recommended for future large-scale trace element analysis using similar ICP-MS methods.
  • This ensures detection of a wider range of non-essential elements.