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Updated: Dec 9, 2025

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
Published on: August 17, 2022
Noninvasive Preimplantation Genetic Testing for Aneuploidy (niPGT-A): The first Brazilian baby
José Gonçalves Franco1,2, Laura Diniz Vagnini2, Claudia Guilhermino Petersen1,2
1Center for Human Reproduction - Prof. Franco Jr. Ribeirão Preto Brazil Center for Human Reproduction - Prof. Franco Jr., Ribeirão Preto, Brazil.
Abstract:
Recently, a new technology known as the Noninvasive Preimplantation Genetic Testing for Aneuploidy (niPGT-A) emerged, using cell-free DNA present in the spent culture media of human blastocysts. Unlike PGT-A, in which only trophectoderm cells are used, niPGT-A reflects the ploidy state of these cells and internal cell mass, suggesting that this new technology may be less prone to error, being more reliable than the invasive test. The aim of the present study was to report the first occurrence of childbirth following niPGT-A in Brazil.
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