Related Experiment Video

Updated: Dec 9, 2025

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

1.9K

Higher blood glucose impairs cardiac autonomic modulation in fasting and after carbohydrate overload in adults

Caroline Maria Oliveira1, Ana Carolina Ghezzi2, Lucieli Teresa Cambri1,3

  • 1Graduate Program in Nutrition, Foods and Metabolism, Federal University of Mato Grosso, Cuiabá, MT 78060-900, Brazil.

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme
|September 8, 2020
PubMed

Insights

Higher blood glucose levels, even within the normal range, impair cardiac autonomic modulation. This effect is evident both in a fasting state and after carbohydrate intake, impacting heart rate variability.

Area of Science:

  • Cardiology
  • Endocrinology
  • Autonomic Nervous System Function

Background:

  • Cardiac autonomic modulation is crucial for cardiovascular health.
  • Elevated blood glucose levels are associated with various health complications.
  • Understanding the impact of blood glucose on autonomic function is vital for preventative strategies.

Purpose of the Study:

  • To investigate the influence of blood glucose levels on cardiac autonomic modulation.
  • To compare autonomic function in individuals with lower versus higher fasting blood glucose.
  • To assess changes in autonomic modulation after carbohydrate overload in relation to blood glucose levels.

Main Methods:

  • 108 participants were categorized into lower and higher blood glucose groups based on median fasting glucose.
  • Heart rate variability (HRV) indices were measured under fasting and post-dextrose overload conditions.
  • Anthropometric and blood pressure measurements were recorded.

Main Results:

  • Higher blood glucose group exhibited increased body mass, abdominal circumference, and blood pressure.
  • Carbohydrate overload led to increased SD2, SDNN, LF indices, and LF/HF ratio, with decreased HF.
  • The higher blood glucose group showed lower HRV indices and impaired autonomic response to carbohydrate overload.
  • Post-dextrose glycemia correlated negatively with HRV indices.

Conclusions:

  • Higher fasting blood glucose impairs cardiac autonomic modulation.
  • Carbohydrate overload negatively impacts cardiac autonomic modulation.
  • Individuals with higher blood glucose, even within the normal range, demonstrate impaired cardiac autonomic function.

Keywords:
activité physiqueautonomic nervous systemblood pressuredextroseheart rate variabilityobesityobésitéphysical activitysystème nerveux autonometension artériellevariabilité de la fréquence cardiaque

More Related Videos

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

70.8K
A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli08:01

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

9.3K

Related Concept Videos

Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.8K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
3.4K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.8K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.2K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
5.9K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
668