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Functional gadolinium-based nanoscale systems for cancer theranostics
Haonan Li1, Yujun Zeng1, Hu Zhang2
1Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract:
Cancer theranostics is a new strategy for combating cancer that integrates cancer imaging and treatment through theranostic agents to provide an efficient and safe way to improve cancer prognosis. Design and synthesis of these cancer theranostic agents are crucial since these agents are required to be biocompatible, tumor-specific, imaging distinguishable and therapeutically efficacious. In this regard, several types of gadolinium (Gd)-based nanomaterials have been introduced to combine different therapeutic agents with Gd to enhance the efficacy of therapeutic agents. At the same time, the entire treatment procedure could be monitored via imaging tools due to incorporation of Gd ions, Gd chelates and Gd/other imaging probes in the theranostic agents. This review aims to overview recent advances in the Gd-based nanomaterials for cancer theranostics and perspectives for Gd nanomaterial-based cancer theranostics are provided.
Insights
Gadolinium-based nanomaterials offer a dual approach for cancer theranostics, integrating imaging and therapy. This review explores recent advances in these nanomaterials for improved cancer treatment and monitoring.
Area of Science:
- Nanomedicine
- Biotechnology
- Materials Science
Background:
- Cancer theranostics combines imaging and treatment for improved patient outcomes.
- Theranostic agents require biocompatibility, tumor specificity, and therapeutic efficacy.
- Gadolinium (Gd)-based nanomaterials are emerging as versatile platforms for cancer theranostics.
Purpose of the Study:
- To review recent advancements in Gd-based nanomaterials for cancer theranostics.
- To highlight the design and synthesis strategies for effective theranostic agents.
- To discuss the future perspectives of Gd nanomaterial-based cancer theranostics.
Main Methods:
- Literature review of recent research on Gd-based nanomaterials for cancer theranostics.
- Analysis of studies focusing on the integration of imaging and therapeutic functionalities.
- Synthesis and characterization of Gd-based theranostic agents.
Main Results:
- Gd-based nanomaterials can effectively combine therapeutic agents with Gd for enhanced efficacy.
- Incorporation of Gd ions, chelates, or probes allows for real-time monitoring via imaging.
- These nanomaterials demonstrate potential for tumor-specific targeting and treatment.
Conclusions:
- Gd-based nanomaterials represent a promising strategy for advancing cancer theranostics.
- Further research is needed to optimize their design for clinical translation.
- These agents offer a pathway to more efficient and safer cancer treatment with integrated monitoring.
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