Related Experiment Video
Updated: Dec 9, 2025
05:59
Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
Published on: December 4, 2015
9.7K
Classical swine fever virus: the past, present and future
Llilianne Ganges1, Helen R Crooke2, Jose Alejandro Bohórquez1
1OIE Reference Laboratory for Classical Swine Fever, Institute of Agrifood Research and Technology, Centre de Recerca en Sanitat Animal (CReSA), 08193 Barcelona, Spain.
Virus Research
|September 8, 2020
Summary
Classical swine fever (CSF) remains a significant global threat to swine health and the economy. This review details recent advances in CSF virus (CSFV) research, diagnostics, and vaccine development to combat persistent and re-emerging outbreaks.
Area of Science:
- Veterinary Virology
- Epizootic Disease Research
- Animal Health
Background:
- Classical swine fever (CSF) is a highly contagious viral disease impacting swine globally.
- Its significant economic consequences necessitate international reporting and stringent control measures.
- Despite eradication efforts, CSF virus (CSFV) persists in some regions, leading to recurrent outbreaks.
Purpose of the Study:
- To provide a comprehensive review of current knowledge on CSFV.
- To highlight recent advancements in CSFV research, diagnostics, and vaccine development.
- To identify future research needs for improved disease control.
Main Methods:
- Literature review of fundamental CSFV research.
- Analysis of recent progress in diagnostics and vaccine development.
- Synthesis of findings on viral genetics, pathogenesis, immunity, and host interactions.
Main Results:
- Updated insights into pestivirus genetic diversity and taxonomy.
- Progress in understanding CSFV pathogenesis, immunity, and virus-host interactions.
- Review of diagnostic tool improvements and challenges in developing marker vaccines for surveillance.
Conclusions:
- CSFV control requires ongoing research into its complex biology and epidemiology.
- Development of effective marker vaccines compatible with surveillance is crucial.
- Further research is needed to address knowledge gaps and enhance global disease management strategies.
Keywords:
CSFCSFVDiagnostic toolsDisease controlDisease pathogenesisImmunityTaxonomyVaccine developmentVirulence determinantsMore Related Videos
Related Concept Videos
00:57Viral Recombination
24.6K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
24.6K
01:29Viruses with RNA Genomes
517
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
517
00:36Viral Mutations
39.0K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
39.0K
01:29Subviral Agents
350
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
350
01:29Microorganisms in Medicine and Therapeutics
749
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
749
02:33Retroviruses
14.3K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
14.3K