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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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A 3D Organotypic Melanoma Spheroid Skin Model
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Targeted Therapies for Melanoma.

Karel Smetana1,2, Lukáš Lacina1,2,3, Ondřej Kodet1,2,3

  • 1Institute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.

Cancers
|September 9, 2020
PubMed
Summary

The global incidence of cutaneous malignant melanoma (CMM) is rising. Early detection and understanding risk factors are crucial for combating this skin cancer.

Keywords:
BRAF V600 mutationadvanced therapy of melanomamelanomatherapeutic resistance

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Area of Science:

  • Dermatology and Oncology
  • Epidemiology of Skin Cancer

Background:

  • Cutaneous malignant melanoma (CMM) incidence is increasing globally.
  • Understanding the epidemiology and risk factors for CMM is critical.

Discussion:

  • Further research is needed to elucidate the specific drivers behind the rising CMM rates.
  • Public health initiatives focusing on sun protection and early detection are paramount.

Key Insights:

  • The escalating worldwide incidence of CMM highlights a significant public health concern.
  • Effective prevention strategies and improved diagnostic methods are essential.

Outlook:

  • Continued monitoring of CMM trends and investigation into novel therapeutic approaches are warranted.
  • Global collaboration is essential to address the increasing burden of melanoma.