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Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing.

Mohsin Ali Badshah1, Na Yoon Koh2, Abdul Wasy Zia3

  • 1Department of Chemical and Biomolecular Engineering, University of California-Irvine, Irvine, CA 92697, USA.

Nanomaterials (Basel, Switzerland)
|September 9, 2020
PubMed
Summary

Metal-enhanced fluorescence (MEF) utilizes plasmonics for highly sensitive detection. This review covers MEF mechanisms, fabrication, and biosensor applications in diagnostics and forensics.

Keywords:
biosensorslocalized surface plasmon resonancelow-dimensional materialsmetal-enhanced fluorescencemetallic nanostructuresnanofabricationplasmonic nanostructures

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Area of Science:

  • Surface plasmonics and nanophotonics
  • Biomedical engineering and biosensing
  • Materials science and nanotechnology

Background:

  • Metal-enhanced fluorescence (MEF) leverages surface plasmons interacting with metallic nanostructures.
  • This phenomenon generates electromagnetic fields that significantly boost fluorescence detection sensitivity.
  • MEF is crucial for advancements in medical diagnostics, forensic science, and biotechnology.

Purpose of the Study:

  • To review the fundamental mechanism of metal-enhanced fluorescence.
  • To critically assess recent developments in plasmonic nanostructure fabrication for MEF.
  • To summarize the implications of MEF-based biosensors for various applications.

Main Methods:

  • Review of existing literature on MEF mechanisms and plasmonic nanostructure fabrication.
  • Critical comparison of fabrication methods based on resolution, design flexibility, and throughput.
  • Summary and analysis of current MEF-based biosensor technologies and their applications.

Main Results:

  • Detailed explanation of the basic MEF mechanism involving light-metal nanostructure interaction.
  • Overview of advancements in fabricating plasmonic nanostructures for enhanced fluorescence.
  • Summary of practical applications in food control, medical diagnostics, and forensic science.

Conclusions:

  • MEF offers a powerful approach to enhance fluorescence-based detection sensitivity.
  • Fabrication methods vary in performance, impacting biosensor design and throughput.
  • Future research should explore novel materials and hybrid techniques for improved MEF biosensors.