Surface Interactions between Bacterial Nanocellulose and B-Complex Vitamins

Area of Science:

• Biomaterials Science
• Materials Chemistry
• Nanotechnology

Background:

• Bacterial nanocellulose (BNC) is a promising biomaterial with unique properties.
• B complex vitamins are essential nutrients with various health implications.
• Understanding the interaction between BNC and vitamins is crucial for developing novel delivery systems.

Purpose of the Study:

• To investigate the adsorption and desorption kinetics of B complex vitamins on bacterial nanocellulose films.
• To elucidate the role of pH in modulating vitamin-BNC interactions and film morphology.
• To develop a model for vitamin binding and release from BNC films.

Main Methods:

• In situ generation of bacterial nanocellulose films using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D).
• Real-time monitoring of vitamin adsorption and desorption under varying pH conditions (pH 2 and 6.5).
• Atomic Force Microscopy (AFM) to assess surface morphology changes and rugosity.

Main Results:

• QCM-D successfully quantified vitamin adsorption and release based on frequency and dissipation changes.
• pH significantly influenced the desorption process and the morphology of the BNC-vitamin interface.
• AFM revealed pH-dependent changes in surface rugosity, correlating with film relaxation.

Conclusions:

• A pH-dependent model for vitamin binding and release from BNC films was proposed.
• The study demonstrates the potential of BNC as an efficient carrier for B complex vitamin delivery.
• The findings pave the way for optimizing BNC-based systems for targeted nutrient delivery.