Related Experiment Video
Updated: Dec 9, 2025

Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling Events
Published on: August 27, 2019
Teaching hydrogels how to move like an earthworm
Lilit Yeghiazarian1, Hitesh Arora2, Vasile Nistor3
1UCLA School of Public Health, CHS 51-239D, Los Angeles, CA 90095, USA.
Abstract:
Breaking of symmetry is an important principle employed in nature to achieve directional movement in systems of various dimensional scales. The same principle can be utilized in engineered devices. Here we highlight recent work on directed motion and transport capacity of environmentally sensitive polymer gels. The directional motion of cylindrical hydrogels is driven by spatially and temporally controlled propagation of volume phase transitions along their length. This system could potentially be used in a wide variety of areas including biochemical test systems, targeted drug delivery and "soft" medical tools.

