Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

2.5K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
2.5K
Structure and Nomenclature of Epoxides02:38

Structure and Nomenclature of Epoxides

7.6K
Cyclic ethers are heterocyclic compounds with an oxygen atom in the ring along with carbon atoms. They are named depending on the number of carbon atoms present in their ring system. Cyclic ethers with a three-membered ring system are called “oxirane”, four-membered ring systems as “oxetane”, five-membered ring systems as “oxolane”, and six-membered ring systems as “oxane”. The cyclic structure of these rings imposes angle strain, and this strain...
7.6K
Preparation of Epoxides03:00

Preparation of Epoxides

8.9K
Overview
Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...
8.9K
Phosphodiester Linkages01:01

Phosphodiester Linkages

108.8K
Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
108.8K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.4K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
2.4K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

2.1K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mussel-Inspired Catechol-Functionalized Redox-Active Polypeptides for Energy Applications.

Biomacromolecules·2026
Same author

Adaptable microplastic classification using similarity learning on µFTIR spectra collected from µFTIR focal plane array imaging.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Author Correction: Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan.

Nature communications·2025
Same author

Corrigendum to "Morphologic design of sugar-based polymer nanoparticles for delivery of antidiabetic peptides" [Journal of Controlled Release 334 (2021) 1-10].

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

A bioinspired and degradable riboflavin-containing polypeptide as a sustainable material for energy storage.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Structural Metamorphoses of d-Xylose Oxetane- and Carbonyl Sulfide-Based Polymers <i>In Situ</i> during Ring-Opening Copolymerizations.

Journal of the American Chemical Society·2023

Related Experiment Video

Updated: Dec 9, 2025

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

29.5K

Cross-linked and functionalized polyester materials constructed using ketoxime ether linkages.

Brooke A Van Horn1, Karen L Wooley1

  • 1Washington University in Saint Louis, Center for Materials Innovation, Department of Chemistry and Department of Radiology, Saint Louis, Missouri, USA. klwooley@wustl.edu.

Soft Matter
|September 9, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a simple method to modify ketone-containing poly(ε-caprolactone)s, creating new gel and nanoparticulate materials. This graft functionalization and cross-linking approach yields robust, degradable polymers with tunable properties.

More Related Videos

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

22.8K
Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
08:12

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

Published on: December 16, 2022

3.7K

Related Experiment Videos

Last Updated: Dec 9, 2025

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

29.5K
Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

22.8K
Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
08:12

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

Published on: December 16, 2022

3.7K

Area of Science:

  • Polymer Chemistry
  • Materials Science

Background:

  • Ketone-containing poly(ε-caprolactone)s offer potential for functionalization.
  • Developing efficient cross-linking methods is crucial for advanced polymer materials.

Purpose of the Study:

  • To investigate a modular approach for graft functionalization and cross-linking of ketone-containing poly(ε-caprolactone)s.
  • To prepare novel gel and nanoparticulate materials with tunable properties.

Main Methods:

  • Grafting poly(ε-caprolactone--2-oxepane-1,5-dione) with 1-aminooxydodecane.
  • Cross-linking with 1,6-bis(aminooxy)hexane at room temperature.
  • Characterization using gel permeation chromatography, atomic force microscopy, infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis.

Main Results:

  • Successful grafting and cross-linking were achieved, yielding characterizable products.
  • The process retained polymer physical properties with new ketoxime functionalities.
  • Insoluble gels were formed, exhibiting altered melting transition profiles compared to precursors.

Conclusions:

  • A rapid and efficient chemistry for functional and robust hydrolytically-degradable polymer materials was developed.
  • The method allows for the preparation of novel gel and nanoparticulate materials.
  • The resulting materials possess degradable linkages and modified thermal properties.