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Lamellarsomes: metastable polymeric multilamellar aggregates.

Giuseppe Battaglia1, Salvador Tomas2, Anthony J Ryan3

  • 1Department of Engineering Materials, University of Sheffield, The Kroto Research Institute, Sheffield, United KingdomS3 7HQ. g.battaglia@sheffield.ac.uk.

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Researchers created metastable multilamellar aggregates called lamellarsomes through self-assembly. These structures encapsulate molecules and release them when exposed to osmotic shock, offering potential for controlled delivery.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Amphiphilic block copolymers self-assemble in aqueous solutions.
  • Understanding self-assembled nanostructures is crucial for drug delivery and materials science.
  • Metastable structures offer unique properties compared to thermodynamically stable phases.

Purpose of the Study:

  • To report the formation and characterization of novel metastable multilamellar aggregates (lamellarsomes).
  • To investigate the internal structure and encapsulation capabilities of these lamellarsomes.
  • To explore the cargo release mechanisms modulated by the metastable nature of lamellarsomes.

Main Methods:

  • Spontaneous self-assembly of amphiphilic block copolymers in water.
  • Transmission electron microscopy (TEM) for structural analysis.
  • Fast Fourier Transform (FFT) analysis to determine internal lamellar structure.
  • Encapsulation studies with hydrophilic molecules.
  • Osmotic shock experiments to study cargo release.

Main Results:

  • Formation of disperse metastable multilamellar aggregates (lamellarsomes) with sizes from nanometers to micrometers.
  • Detailed analysis revealed internal lamellar structures characteristic of lyotropic lamellar phases.
  • Lamellarsomes demonstrated long lifetimes and effective encapsulation of hydrophilic molecules.
  • Mild osmotic shock induced the formation of more permeable unilamellar vesicles, modulating cargo release.

Conclusions:

  • Lamellarsomes represent a novel class of self-assembled metastable nanostructures.
  • Their unique lamellar organization and tunable release properties are significant.
  • These findings open avenues for applications in controlled drug delivery and nanotechnology.