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Related Concept Videos

Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jul 12, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Drug diffusion from polymer core-shell nanoparticles.

Gavin A Buxton1, Nigel Clarke1

  • 1Department of Chemistry, University of Durham, Durham, UKDH1 3LE. nigel.clarke@durham.ac.uk.

Soft Matter
|September 9, 2020
PubMed
Summary

Computer simulations reveal how polymer core-shell nanoparticles release drugs. Shell swelling, influenced by pH, controls drug diffusion rates, offering targeted delivery potential.

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Computational Chemistry

Background:

  • Polymer core-shell nanoparticles offer tunable drug delivery.
  • Shell properties can be engineered for specific release profiles.
  • pH-responsive polymer gels are promising for targeted drug release.

Purpose of the Study:

  • To investigate drug diffusion from polymer core-shell nanoparticles using computer simulations.
  • To analyze the impact of shell swelling on drug release rates.
  • To explore physical and chemical barriers affecting drug release.

Main Methods:

  • Utilized computer simulations to model nanoparticle deformation.
  • Employed structural and fluid dynamics simulations.
  • Incorporated enthalpic interactions to study release barriers.

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Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
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Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

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Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
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Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

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Related Experiment Videos

Last Updated: Jul 12, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

Main Results:

  • Shell swelling significantly influences drug diffusion rates.
  • Expanding shells create more space, enhancing drug release.
  • Identified physical and chemical factors governing drug release.

Conclusions:

  • Computer simulations effectively capture the physics of polymer core-shell nanoparticles for drug delivery.
  • Shell swelling is a key mechanism for controlling targeted drug release.
  • Understanding these interactions is crucial for designing advanced drug delivery systems.