Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The fragile-X syndrome.

H Z Ho1, T J Glahn, J C Ho

  • 1Department of Psychology, University of California Santa Barbara 93106.

Developmental Medicine and Child Neurology
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal exposure to nickel and atopic dermatitis at age 3 years: a birth cohort study with cytokine profiles.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Resveratrol enhanced chemosensitivity by reversing macrophage polarization in breast cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2021
Same author

Paediatric glaucoma in Hong Kong: a multicentre retrospective analysis of epidemiology, presentation, clinical interventions, and outcomes.

Hong Kong medical journal = Xianggang yi xue za zhi·2021
Same author

Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy.

The Journal of clinical endocrinology and metabolism·2012
Same author

Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery.

Journal of biomaterials applications·2011
Same author

Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct.

Reproduction (Cambridge, England)·2010
Same journal

Predictive ability of the Hammersmith Neonatal Neurological Examination for identifying severe neurodevelopmental impairment in infants born very preterm.

Developmental medicine and child neurology·2026
Same journal

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management.

Developmental medicine and child neurology·2026
Same journal

Hammersmith Infant Neurological Examination global scores for predicting neurodevelopmental outcomes after 2 years of age: A systematic review and meta-analysis.

Developmental medicine and child neurology·2026
Same journal

Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series.

Developmental medicine and child neurology·2026
Same journal

What is the impact of childhood-onset disability research - and what should it be?

Developmental medicine and child neurology·2026
Same journal

Sleep disturbances in children with cerebral palsy, their siblings, and parents: A qualitative descriptive study.

Developmental medicine and child neurology·2026
See all related articles

Fragile-X syndrome exhibits varied behaviors and may cause a genetic autism subtype. Unusual inheritance patterns, like transmission via normal males, challenge traditional X-linked models and genetic counseling approaches.

Area of Science:

  • Behavioral genetics
  • Neurodevelopmental disorders
  • Human genetics

Background:

  • Fragile-X syndrome (FRAX) displays significant behavioral variability and lacks a defined psychological profile.
  • The association between FRAX and autism suggests a potential genetic subtype of autism.
  • Observed transmission patterns deviate from classical X-linked inheritance, particularly concerning intellectually normal males.

Purpose of the Study:

  • To address the variability in fragile-X syndrome's behavioral manifestations.
  • To investigate the potential role of FRAX as a genetic subtype of autism.
  • To explore atypical inheritance patterns and their implications for genetic counseling and models.

Main Methods:

  • Review of existing literature on fragile-X syndrome and its behavioral genetics.

Related Experiment Videos

  • Analysis of transmission patterns, including cases involving intellectually normal males.
  • Consideration of emerging research on folic acid treatment and molecular biology techniques.

    • Main Results:

    • The behavioral and psychological presentation of FRAX is highly variable.
    • FRAX is associated with autism, potentially representing a specific genetic subtype.
    • Non-classical X-linked inheritance is observed, notably transmission through unaffected males.

    Conclusions:

    • The variability and atypical inheritance of FRAX necessitate further research in behavioral genetics.
    • Understanding these patterns is crucial for accurate genetic counseling and refining genetic models.
    • Advanced molecular biology techniques are essential for elucidating the mechanisms underlying FRAX phenotype.