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RNA Splicing: Basic Aspects Underlie Antitumor Targeting

Alzahraa A M Fergany1, Victor V Tatarskiy2

  • 1Department of Occupational and Environmental Health, Graduate School of Pharmaceutical Science, Tokyo University of Science, Chiba, Japan.

Recent Patents on Anti-Cancer Drug Discovery
|September 9, 2020
PubMed
Abstract

Insights

RNA splicing, a key gene expression process, is crucial in cancer. Aberrant splicing drives tumor progression and affects drug response, offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • RNA splicing is essential for gene expression, involving intron removal and exon arrangement to create functional proteins.
  • Aberrant RNA splicing is increasingly recognized as a significant factor in cancer development and progression.

Purpose of the Study:

  • To review the critical role of RNA splicing in cancer biology.
  • To highlight splicing abnormalities as potential therapeutic targets for cancer treatment.

Main Methods:

  • Discussion of the literature on mRNA splicing in carcinogenesis.
  • Analysis of the impact of aberrant splicing on patient response to cancer therapies.

Main Results:

  • Aberrant mRNA splicing contributes to the initiation and advancement of various cancers.
  • Splicing alterations can influence the efficacy of chemotherapy and targeted drug treatments.

Conclusions:

  • Dysregulated RNA splicing is a clinically relevant mechanism in cancer.
  • Targeting RNA splicing pharmacologically presents a promising avenue for novel cancer therapies.
Keywords:
CancerRNA splicingmolecular drug targetsprotein kinase inhibitors.therapy

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