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Association between vascular measures and cognitive function in type 2 diabetes.

Serena Low1, Tze Pin Ng2, Chin Leong Lim3

  • 1Diabetes Centre, Admiralty Medical Centre, Singapore, Block 676, Level 4, Kampung Admiralty, Woodlands Drive 71, 730676, Singapore; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, 90 Yishun Central, 768828, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore.

Journal of Diabetes and Its Complications
|September 9, 2020
PubMed
Summary
This summary is machine-generated.

Vascular measures like pulse pressure and diastolic blood pressure are linked to cognitive decline in type 2 diabetes patients. These findings highlight the importance of monitoring vascular health for brain function in this population.

Keywords:
Cognitive functionPulse pressureType 2 diabetes

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Area of Science:

  • Cardiovascular Medicine
  • Neuroscience
  • Diabetes Research

Background:

  • Type 2 diabetes (T2D) is associated with an increased risk of cognitive impairment.
  • Vascular dysfunction is a known complication of T2D and may contribute to cognitive decline.
  • Understanding the specific vascular measures linked to cognitive performance in T2D is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the correlation between various vascular measures and cognitive performance in individuals with type 2 diabetes.
  • To identify specific vascular parameters that are independently associated with cognitive function in a T2D cohort.

Main Methods:

  • A cross-sectional study involving 1167 patients aged 45 years and older with T2D.
  • Vascular measures included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP), pulse wave velocity (PWV), and augmentation index (AI).
  • Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS); statistical analyses adjusted for demographics, education, depression, and clinical covariates.

Main Results:

  • In adjusted analyses, peripheral pulse pressure (PP), aortic PP, and aortic diastolic blood pressure (DBP) were significantly associated with the RBANS total cognitive score.
  • Peripheral and aortic PP showed negative associations with attention, visuospatial/constructional abilities, and language.
  • The association between aortic DBP and cognitive performance was significant only in older adults (≥60 years).

Conclusions:

  • Peripheral and aortic pulse pressure, along with aortic diastolic blood pressure, are independently correlated with global cognitive performance and specific cognitive domains in individuals with type 2 diabetes.
  • These vascular measures, particularly pulse pressure, may serve as indicators of cognitive impairment risk in T2D.
  • Further research is warranted to elucidate the clinical significance and implications of these vascular-cognitive relationships in T2D management.