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Convalescent plasma as a treatment modality for coronavirus disease 2019 in Sudan
Mozan Osman Hassan1, Asma Ahmed Osman2, Hana Elsir Abd Elbasit3
1Faculty of Medical Laboratory Science, Omdurman Ahlia University, Sudan.
Insights
This study outlines a protocol for using convalescent plasma to treat COVID-19 patients in Sudan. The protocol details patient and donor selection, plasma collection, and transfusion procedures for early to moderate cases.
Area of Science:
- Infectious Diseases
- Hematology
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) presents a significant global health challenge, particularly in regions like Sudan, with limited definitive treatments.
- Convalescent plasma transfusion has emerged as a potential therapeutic option, showing promising clinical improvements in COVID-19 patients.
Purpose of the Study:
- To develop a guiding protocol for the safe and effective use of convalescent plasma in treating early to moderate COVID-19 cases.
- To tailor a treatment protocol for convalescent plasma transfusion specifically for the context of Sudan.
- To provide a framework for future open-label clinical trials on convalescent plasma therapy.
Main Methods:
- A comprehensive protocol was developed based on existing literature and studies on convalescent plasma therapy for COVID-19.
- The protocol includes detailed guidelines on patient and donor selection criteria.
- Instructions cover plasma harvesting, product specifications, dosage, and precautions for collection and transfusion.
Main Results:
- A tailored treatment protocol for convalescent plasma transfusion in Sudan has been established.
- The protocol addresses critical aspects of the transfusion process, from donor screening to patient administration.
- This provides a standardized approach for healthcare authorities and researchers.
Conclusions:
- The developed protocol offers a practical framework for implementing convalescent plasma therapy in Sudan.
- It aims to improve clinical outcomes for COVID-19 patients with early to moderate disease.
- The protocol serves as a foundation for further research and clinical trials in the region.
Abstract:
Coronavirus disease 2019 (COVID-19) is a disease spreading rapidly in Sudan, the rest of the African continent and the world with no known definitive treatment or vaccines. However, among many treatment interventions being tested globally, beneficial effects and clinical improvements have been reported when convalescent plasma is used for treating COVID-19 patients. We prepared a guiding protocol for treating early to moderate COVID-19 patients with plasma transfusion from convalescent COVID-19 patients. This protocol was deduced based on previously published reports and studies that evaluated and tested convalescent plasma as a prospective therapy for COVID-19 patients. The protocol covers instructions on patient and donor selection criteria, plasma harvesting, plasma product specifications, dosage and precautions for convalescent plasma collection and transfusion process. Altogether, we prepared a treatment protocol that is tailored to the context of Sudan to be adopted by Sudan's health authority. Moreover, it will also provide reference for researchers to design open label clinical trials for convalescent plasma transfusion.
