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Related Concept Videos

What are Lipids?01:38

What are Lipids?

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Overview
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What are Lipids?01:31

What are Lipids?

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Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
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Structure of Lipids03:38

Structure of Lipids

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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Lipid Digestion01:06

Lipid Digestion

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Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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Autoxidation of Ethers to Peroxides and Hydroperoxides02:23

Autoxidation of Ethers to Peroxides and Hydroperoxides

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Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.
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Regioselectivity of Electrophilic Additions-Peroxide Effect02:35

Regioselectivity of Electrophilic Additions-Peroxide Effect

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In the presence of organic peroxides, the addition of hydrogen bromide to an alkene yields the isomer that is not predicted by Markovnikov’s rule. For example, the addition of hydrogen bromide to 2-methylpropene in the presence of peroxides gives 1-bromo-2-methylpropane. This addition reaction proceeds via a free radical mechanism, which reverses the regioselectivity. The free radical reaction mechanism involves three stages: initiation, propagation, and termination.
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Lipid peroxidation in tumour cells.

L Masotti1, E Casali, T Galeotti

  • 1Institute of Biological Chemistry, University of Parma, Italy.

Free Radical Biology & Medicine
|January 1, 1988
PubMed
Summary

Cancer cells exhibit altered reactive oxygen species metabolism and resistant tumor membrane lipids, potentially driving uncontrolled proliferation. This study proposes a hypothetical sequence of events for further in vivo cancer research.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Evidence suggests a disturbance in reactive oxygen species (ROS) metabolism within cancer cells.
  • Tumor cell membranes display unique resistance to oxy-radical-induced peroxidation, linked to cellular growth.

Purpose of the Study:

  • To propose a hypothetical sequence of events linking metabolic disturbances to uncontrolled cancer cell proliferation.
  • To provide a framework for future in vivo investigations into tumor growth and invasion.

Main Methods:

  • Review and synthesis of existing studies on ROS metabolism in cancer.
  • Analysis of characteristic behaviors of tumor membrane lipids.
  • Hypothetical modeling of cellular events driving tumor progression.

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Electrochemotherapy of Tumours
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Main Results:

  • A hypothetical model is presented outlining a sequence of events.
  • The model connects altered ROS metabolism and lipid peroxidation resistance to uncontrolled cell growth.
  • The proposed scheme highlights the role of membrane lipid behavior in cancer progression.

Conclusions:

  • Altered ROS metabolism and lipid peroxidation resistance are key factors in cancer cell proliferation.
  • The proposed hypothetical framework requires further in vivo validation.
  • Understanding these mechanisms can inform future cancer research and therapeutic strategies.