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Targeting Epigenetics in Lung Cancer

Yvonne L Chao1, Chad V Pecot1

  • 1Department of Medicine, Division of Hematology and Oncology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.

Cold Spring Harbor Perspectives in Medicine
|September 9, 2020
PubMed

Insights

Lung cancer

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic alterations, including DNA methylation and histone modifications, contribute to lung cancer's complex nature.
  • These epigenetic changes drive tumor heterogeneity, posing challenges for effective treatment development.

Purpose of the Study:

  • To review epigenetic alterations in lung cancer pathogenesis and progression.
  • To summarize clinical applications of targeting epigenetics in lung cancer treatment.

Main Methods:

  • Literature review of epigenetic mechanisms in lung cancer.
  • Analysis of current clinical strategies targeting epigenetic modifications.

Main Results:

  • Epigenetic landscape significantly impacts lung cancer development and progression.
  • Targeting epigenetic modifications shows promise for novel lung cancer therapies.

Conclusions:

  • Understanding the epigenetic landscape is crucial for overcoming lung cancer heterogeneity.
  • Epigenetic therapies offer a potential avenue for improving lung cancer treatment outcomes.

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