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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Dec 9, 2025

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

179

Targeting Epigenetics in Lung Cancer.

Yvonne L Chao1, Chad V Pecot1

  • 1Department of Medicine, Division of Hematology and Oncology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.

Cold Spring Harbor Perspectives in Medicine
|September 9, 2020
PubMed
Summary

Lung cancer

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic alterations, including DNA methylation and histone modifications, contribute to lung cancer's complex nature.
  • These epigenetic changes drive tumor heterogeneity, posing challenges for effective treatment development.

Purpose of the Study:

  • To review epigenetic alterations in lung cancer pathogenesis and progression.
  • To summarize clinical applications of targeting epigenetics in lung cancer treatment.

Main Methods:

  • Literature review of epigenetic mechanisms in lung cancer.
  • Analysis of current clinical strategies targeting epigenetic modifications.

Main Results:

  • Epigenetic landscape significantly impacts lung cancer development and progression.

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  • Targeting epigenetic modifications shows promise for novel lung cancer therapies.

    • Conclusions:

    • Understanding the epigenetic landscape is crucial for overcoming lung cancer heterogeneity.
    • Epigenetic therapies offer a potential avenue for improving lung cancer treatment outcomes.