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Protective role of lactic acid bacteria and yeasts as dietary carcinogen-binding agents - a review

P F Cuevas-González1, A F González-Córdova1, B Vallejo-Cordoba1

  • 1Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD), Carretera Gustavo Enrique Astiazarán Rosas, Hermosillo, Mexico.

Critical Reviews in Food Science and Nutrition
|September 9, 2020
PubMed

Insights

Lactic acid bacteria and yeast can bind to dietary carcinogens, potentially reducing cancer risk. These safe, cost-effective microbial agents offer a promising alternative to traditional cancer prevention methods.

Area of Science:

  • Microbiology
  • Food Science
  • Cancer Research

Background:

  • Dietary carcinogens are linked to cancer development.
  • Conventional methods to reduce exposure are often inefficient and costly.
  • Microbiological approaches are emerging as a viable alternative.

Purpose of the Study:

  • To review the role of lactic acid bacteria (LAB) and yeast in binding dietary carcinogens.
  • To explore the potential of these microorganisms in reducing cancer risk.
  • To discuss the mechanisms and factors influencing carcinogen binding by microbes.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Analysis of research on Lactobacillus, Bifidobacterium, and Saccharomyces genera.
  • Examination of proposed mechanisms for carcinogen binding.

Main Results:

  • LAB and yeast, particularly strains from Lactobacillus, Bifidobacterium, and Saccharomyces, show potential as carcinogen-binding agents.
  • Microbial binding reduces carcinogen bioaccessibility and subsequent toxic effects.
  • The exact mechanisms of binding require further elucidation.

Conclusions:

  • Lactic acid bacteria and yeast represent a promising strategy for mitigating dietary carcinogen exposure.
  • These microorganisms may play a protective role against diet-related cancers.
  • Further research is needed to fully understand and optimize microbial carcinogen-binding capabilities.
Keywords:
binding agentscancerlactic acid bacteriayeast

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