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Updated: Dec 9, 2025

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
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Study of usefulness of low-dose IgG for patients with septic disseminated intravascular coagulation

Gaku Takahashi1, Shigehiro Shibata1

  • 1Department of Critical Care & Disaster, General Medicine, Iwate Medical University, Iwate, Japan.

Biomarkers in Medicine
|September 9, 2020
PubMed

Aim: Improving prognosis with intravenous IgG (IVIG) has been ruled out in a large, multicenter, randomized controlled trial in patients with sepsis. However, its efficacy in the case of septic disseminated intravascular coagulation (DIC) has not been well studied. Results, materials & methods: We retrospectively evaluated the effects of IVIG on severity scores and 28-day survival in patients with septic DIC. A total of 80 patients with septic DIC were enrolled. Changes in infection-related markers, coagulation-related markers, severity scores and 28-day survival were compared between IVIG-treated and untreated groups. Discussion & conclusion: IVIG treatment significantly reduced the Sequential Organ Failure Assessment scores and DIC scores and increased platelet counts, but the 28-day mortality rate did not decrease significantly.

Keywords:
APACHEDICIVIGIgGSOFApresepsinsepsis

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