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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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1.4K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Core-shell nanostructures: perspectives towards drug delivery applications.

Raj Kumar1, Kunal Mondal2, Pritam Kumar Panda3

  • 1Faculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan-52900, Israel. rk7410@gmail.com.

Journal of Materials Chemistry. B
|September 9, 2020
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Core-shell nanoparticles offer advanced drug delivery by combining multiple functionalities on a single nanocarrier. This review highlights their design, properties, and applications in targeted therapies for personalized medicine.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Nanosystems show promise in drug delivery and biomedical applications.
  • Controlled drug/gene delivery is often limited by physicochemical properties.
  • Core-shell nanoparticles offer unique advantages for targeted delivery.

Purpose of the Study:

  • To review advancements in core-shell nanoparticle systems for drug delivery.
  • To explore structure-property relationships and functionalization strategies.
  • To discuss applications in drug delivery, biomedical fields, and tissue engineering.

Main Methods:

  • Review of state-of-the-art developments in core-shell nanoparticle systems.
  • Analysis of structure-property relationships and parameter control.
  • Exploration of surface modification and functionalization techniques.

Main Results:

  • Core-shell nanoparticles enable selective mingling of properties for enhanced drug delivery.
  • Various types (metallic, magnetic, silica, upconversion, carbon-based) have been developed.
  • Surface modification and functionalization are key to achieving desired properties.

Conclusions:

  • Core-shell nanoparticles are promising nanocarriers for controlled and targeted drug delivery.
  • Further research into multi-core/shell systems can advance personalized healthcare.
  • These systems are crucial for developing next-generation nano-therapies.