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Papillary eccrine adenoma. A light microscopic and immunohistochemical study.
1Department of Pathology, Pennsylvania State University College of Medicine, Hershey 17033.
Journal of the American Academy of Dermatology
|May 1, 1988
Summary
Papillary eccrine adenoma, a rare benign neoplasm, can be locally aggressive. Immunohistochemistry supports its differentiation towards the eccrine secretory coil.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Papillary eccrine adenoma is a rare benign sweat gland neoplasm.
- It can present with a locally aggressive clinical course.
Purpose of the Study:
- Discuss light microscopic findings in two cases.
- Emphasize differential diagnosis from other sweat gland neoplasms.
- Investigate the neoplastic differentiation using immunohistochemistry.
Main Methods:
- Light microscopy of two papillary eccrine adenoma cases.
- Immunohistochemistry using antibodies for epithelial antigens.
Main Results:
- Detailed light microscopic features were analyzed.
- Immunohistochemistry showed positivity for carcinoembryonic antigen, S-100 protein, and epithelial membrane antigen.
- These markers support differentiation towards the eccrine secretory coil.
Conclusions:
- Papillary eccrine adenoma is a distinct benign entity.
- Immunohistochemistry is crucial for diagnosis and understanding differentiation.
- Accurate diagnosis is essential due to potential local aggressiveness.