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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Cognitive and vascular function in older adults with and without CKD
Mary Hannan1, Eileen G Collins2, Shane A Phillips3
1College of Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Aging Clinical and Experimental Research
|September 9, 2020
Summary
Older adults with preclinical cognitive impairment and chronic kidney disease (CKD) show distinct cognitive and vascular function. Vascular function indicators may relate to cognitive function in this population.
Area of Science:
- Gerontology
- Nephrology
- Neurology
Background:
- Cognitive impairment is common in aging and linked to chronic kidney disease (CKD).
- Vascular dysfunction is a suspected cause of cognitive decline, especially in older adults with CKD.
- Preclinical cognitive impairment affects older adults, with CKD potentially exacerbating deficits.
Purpose of the Study:
- To compare cognitive function and vascular compliance in older adults with and without CKD who have preclinical cognitive impairment.
- To investigate the relationship between cognitive function and vascular compliance in these groups.
Main Methods:
- Cross-sectional study of 48 older adults (24 with CKD, 24 without) with preclinical cognitive impairment.
- Assessed global cognition and executive function using standardized tests.
- Measured vascular compliance using tonometry and ultrasound, including carotid-femoral pulse wave velocity.
Main Results:
- Significant differences in cognitive function and some vascular indicators were observed between older adults with and without CKD.
- Global cognition correlated with carotid-femoral pulse wave velocity (r = -0.36, p = 0.02) in the total sample.
- No significant correlation was found between vascular function and executive function.
Conclusions:
- Older adults with preclinical cognitive impairment and CKD exhibit different cognitive and vascular profiles compared to those without CKD.
- Vascular function, specifically pulse wave velocity, may be associated with cognitive function in older adults.
- Assessment of both cognitive and vascular health is recommended for older adults with preclinical cognitive impairment, particularly those with CKD.
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