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Related Experiment Videos

Immunologic mechanisms in psoriasis.

A B Gottlieb1

  • 1Laboratory of Investigative Dermatology, Rockefeller University, New York, NY 10021.

Journal of the American Academy of Dermatology
|June 1, 1988
PubMed
Summary
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Psoriasis involves activated T cells and keratinocytes expressing human lymphocyte antigen (HLA)-DR. These immune abnormalities are reversible with therapy and linked to psoriatic arthritis, suggesting a role in disease chronicity.

Area of Science:

  • Immunology
  • Dermatology
  • Pathogenesis

Background:

  • Psoriasis is a chronic inflammatory skin disease.
  • The role of the immune system in psoriasis pathogenesis is complex and not fully understood.

Purpose of the Study:

  • To review the evidence for the immunopathogenesis of psoriasis.
  • To explore the role of T lymphocytes and keratinocytes in psoriatic lesions.

Main Methods:

  • Review of existing literature on psoriasis immunopathogenesis.
  • Analysis of immunological findings in psoriatic plaques, including T cell activation markers and human lymphocyte antigen (HLA)-DR expression.

Main Results:

  • Activated T lymphocytes and keratinocytes expressing HLA-DR were identified in psoriatic plaques.

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  • These immunological abnormalities were found to be reversible with medical treatment.
  • Keratinocyte HLA-DR expression correlated with an increased incidence of psoriatic arthritis.

    • Conclusions:

    • Psoriasis pathogenesis likely involves the activation of T cells by HLA-DR expressing keratinocytes and Langerhans cells.
    • This interaction may trigger inflammatory mediators and epidermal growth factors, contributing to disease chronicity.
    • Current therapies for psoriasis primarily target cellular immune function and inflammation.