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Updated: Dec 9, 2025
Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Determination of physiological parameters for endogenous glucose production in individuals using diurnal data
Mariël F van Stee1,2, Shaji Krishnan1, Albert K Groen3,2
1Netherlands Organisation for Applied Scientific Research (TNO), Utrechtseweg 48, Zeist, 3704 HE The Netherlands.
Background:
Triple tracer meal experiments used to investigate organ glucose-insulin dynamics, such as endogenous glucose production (EGP) of the liver are labor intensive and expensive. A procedure was developed to obtain individual liver related parameters to describe EGP dynamics without the need for tracers.
Results:
The development used an existing formula describing the EGP dynamics comprising 4 parameters defined from glucose, insulin and C-peptide dynamics arising from triple meal studies. The method employs a set of partial differential equations in order to estimate the parameters for EGP dynamics. Tracer-derived and simulated data sets were used to develop and test the procedure. The predicted EGP dynamics showed an overall mean R 2 of 0.91.
Conclusions:
In summary, a method was developed for predicting the hepatic EGP dynamics for healthy, pre-diabetic, and type 2 diabetic individuals without applying tracer experiments.
