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Sarcopenic Obesity in Facioscapulohumeral Muscular Dystrophy
Kathryn A Vera1,2, Mary McConville3, Michael Kyba4
1Division of Rehabilitation Science, Medical School, University of Minnesota, Minneapolis, MN, United States.
Frontiers in Physiology
|September 9, 2020
Summary
Adults with facioscapulohumeral muscular dystrophy (FSHD) commonly exhibit sarcopenic obesity, characterized by low muscle mass and high fat mass. This condition may negatively impact quality of life and complicate FSHD management.
Area of Science:
- Neuromuscular Disorders
- Body Composition Analysis
- Metabolic Health
Background:
- Sarcopenic obesity is linked to adverse outcomes in neuromuscular conditions.
- Its prevalence in facioscapulohumeral muscular dystrophy (FSHD) is not well-established.
Purpose of the Study:
- To determine if adults with FSHD meet criteria for sarcopenic obesity.
- To compare body composition between individuals with FSHD and healthy controls.
Main Methods:
- Dual-energy x-ray absorptiometry (DXA) scans were used to assess body composition.
- Appendicular lean mass index (ALMI) and % fat mass (FM) were calculated.
- Ten individuals with FSHD and ten matched controls participated.
Main Results:
- FSHD participants had significantly lower ALMI and higher % FM compared to controls.
- Appendicular lean mass (ALM) and whole-body lean mass (% LM) were reduced in the FSHD group.
- Total body fat mass (FM) was higher in individuals with FSHD.
Conclusions:
- Adults with FSHD frequently meet the definition of sarcopenic obesity.
- Co-existing sarcopenic obesity may worsen quality of life and complicate FSHD management.
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