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Related Concept Videos

Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Dec 9, 2025

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Host-Directed Therapy in Tuberculosis: Targeting Host Metabolism.

Jae-Sung Kim1,2, Ye-Ram Kim1,2, Chul-Su Yang1,2

  • 1Department of Molecular and Life Science, Hanyang University, Ansan, South Korea.

Frontiers in Immunology
|September 9, 2020
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Mycobacterium tuberculosis exploits the Warburg effect, a metabolic shift in immune cells, for its survival. Understanding this interaction may reveal new therapeutic targets for tuberculosis (TB).

Keywords:
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Area of Science:

  • Immunometabolism
  • Cellular Metabolism
  • Infectious Disease Immunology

Background:

  • Mycobacterium tuberculosis (Mtb) evades the innate immune system by surviving within macrophages.
  • Immunometabolism research illuminates how cellular metabolism influences immune cell function during infection.
  • Host immune cells can alter their metabolic pathways, such as shifting to glycolysis (Warburg effect), in response to Mtb.

Purpose of the Study:

  • To review the current understanding of the Warburg effect in the context of Mtb infection.
  • To discuss the role of the Warburg effect in host immune responses to Mtb.
  • To explore how Mtb manipulates host cell metabolism for its survival.

Main Methods:

  • Literature review of immunometabolism and Mtb pathogenesis.
  • Analysis of metabolic reprogramming in immune cells during Mtb infection.
  • Discussion of the dual role of the Warburg effect in host defense and Mtb survival.

Main Results:

  • Immune cells utilize the Warburg effect to enhance antimicrobial and pro-inflammatory responses, including nitric oxide and bioactive lipid production.
  • Mtb exploits the metabolic changes induced by the Warburg effect to promote its own survival and persistence within host cells.
  • The Warburg effect presents a complex interplay, aiding host defense while simultaneously being leveraged by Mtb.

Conclusions:

  • The Warburg effect is a critical metabolic adaptation in immune cells during Mtb infection.
  • Mtb's exploitation of the Warburg effect highlights a key aspect of its pathogenesis.
  • Targeting immunometabolic pathways may offer novel host-directed therapies for tuberculosis (TB).