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A Micropatterning Assay for Measuring Cell Chirality
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A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

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Cell chirality in cardiovascular development and disease

Tasnif Rahman1, Haokang Zhang1, Jie Fan2

  • 1Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

APL Bioengineering
|September 9, 2020
PubMed

Insights

Cell chirality, an intrinsic cell property, is explored for its role in cardiovascular development. This research investigates its connection to heart looping and vascular permeability, offering future research directions.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cardiovascular Science

Background:

  • The cardiovascular system exhibits left-right (LR) asymmetry, crucial for proper function.
  • Congenital heart malformations are linked to disruptions in this asymmetry.
  • The precise origins of cardiovascular asymmetry remain unclear.

Purpose of the Study:

  • To summarize recent advances in cell chirality research.
  • To examine the role of cell chirality in asymmetric cardiovascular development.
  • To review the connection between cell chirality, cardiac looping, and vascular permeability.

Main Methods:

  • Review of multi- and single-cell approaches for studying cell chirality.
  • Examination of research progress in asymmetric cardiovascular development.
  • Analysis of evidence linking cell chirality to cardiac looping and vascular permeability.

Main Results:

  • Cell chirality is an intrinsic LR asymmetric cellular morphological property.
  • Cell chirality has been implicated in heart looping and vascular barrier function.
  • Evidence connects cell chirality to cardiac looping and vascular permeability.

Conclusions:

  • Cell chirality is a key factor in asymmetric cardiovascular development.
  • Understanding cell chirality offers insights into congenital heart malformations.
  • Future research should focus on cell chirality's role in cardiovascular development and disease.

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