Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.6K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
3.2K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.9K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.5K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.5K
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
The Nucleolus02:55

The Nucleolus

10.0K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immediate Background Color Choice in Male and Female <i>Poecilia reticulata</i>.

Animals : an open access journal from MDPI·2026
Same author

Optimizing the Priming Process for Hemoadsorption Combined with Hemodialysis (HAHD): A Two-Stage In Vitro and Clinical Validation Study.

Blood purification·2026
Same author

Bacterial extracellular vesicles exhibit distinct functional potential across biogeographic provinces of the South Pacific Ocean.

The ISME journal·2026
Same author

Robotic traction-assisted en bloc endoscopic resection of a large laterally spreading tumor in the descending duodenum.

Endoscopy·2026
Same author

Biphasic microgel-based bioinks with balanced printability, mechanical stability, and cytocompatibility for extrusion-based bioprinting.

International journal of biological macromolecules·2026
Same author

Naming learner agency at the bedside: FPTAL (from passive reception to active learning) as a dialogic bridge.

Academic medicine : journal of the Association of American Medical Colleges·2026

Related Experiment Video

Updated: Dec 9, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.7K

Long Non-Coding RNA BLACAT1 in Human Cancers.

Tao Ye1, Xiaoqi Yang1, Haoran Liu1,2

  • 1Department of Urology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

Oncotargets and Therapy
|September 9, 2020
PubMed
Summary

Long non-coding RNA BLACAT1 (bladder cancer-associated transcript 1) is implicated in various cancers. This review summarizes its roles in tumor development and its potential as a biomarker or therapeutic target.

Keywords:
BLACAT1cancerlncRNAreview

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

929
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.0K

Related Experiment Videos

Last Updated: Dec 9, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.7K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

929
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.0K

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) regulate gene expression and cellular processes.
  • Aberrant expression of lncRNA BLACAT1 is linked to poor prognosis in human cancers.
  • BLACAT1 dysregulation promotes cancer cell proliferation and metastasis.

Purpose of the Study:

  • To review the functions and mechanisms of BLACAT1 in human cancer development.
  • To discuss BLACAT1's role in various malignancies.
  • To explore BLACAT1's potential as a prognostic biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on BLACAT1 in cancer.
  • Analysis of BLACAT1's regulatory roles in gene transcription, translation, and posttranslational modification.
  • Synthesis of current understanding of BLACAT1's involvement in tumor initiation and progression.

Main Results:

  • BLACAT1 is frequently overexpressed in various cancers.
  • BLACAT1 promotes cancer cell proliferation and metastasis through various molecular mechanisms.
  • Dysregulated BLACAT1 is associated with unfavorable patient prognosis.

Conclusions:

  • BLACAT1 plays a significant role in the occurrence and development of human cancers.
  • BLACAT1 holds promise as a prognostic biomarker for cancer patients.
  • BLACAT1 represents a potential novel therapeutic target for malignancies.