Related Experiment Video
Updated: Dec 9, 2025
05:25
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
Published on: December 29, 2021
2.8K
Cannabidiol as a Novel Therapeutic for Immune Modulation
Nadia Peyravian1,2, Sapna Deo1,2, Sylvia Daunert1,2,3
1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
Immunotargets and Therapy
|September 9, 2020
Summary
Cannabidiol (CBD) demonstrates immune-suppressive effects by modulating key immune pathways and receptors. This research highlights CBD
Area of Science:
- Immunology
- Pharmacology
- Cannabinoid research
Background:
- Cannabidiol (CBD) exhibits immunomodulatory properties.
- Understanding CBD's mechanisms is crucial for its therapeutic development.
Purpose of the Study:
- To review the immune-suppressive effects of CBD.
- To explore CBD's potential as an immune modulator.
Main Methods:
- Analysis of existing studies on CBD's interaction with immune signaling pathways.
- Investigation of CBD's effects on CB1, CB2, and TRPV1 receptors.
- Examination of CBD's impact on JAK/STAT and NLR signaling pathways.
- Assessment of CBD's role in adenosine signaling.
Main Results:
- CBD's immune modulation involves key receptors and signaling pathways.
- Antagonists of CB1, CB2, and TRPV1 receptors reverse CBD's effects.
- CBD inhibits JAK/STAT and NLR pathways, reducing pro-inflammatory cytokines.
- CBD protects cells from damage via adenosine signaling modulation.
Conclusions:
- The evidence strongly supports CBD's immunosuppressive capabilities.
- CBD shows promise as a novel immune modulatory therapeutic.
Related Concept Videos
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
359
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
359
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
567
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
567
01:27Tumor Immunotherapy
1.4K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.4K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
346
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
346
01:29Immune Response Against Viral Pathogens
1.5K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.5K
01:29Inflammatory Bowel Disease IV: Pharmacological Management
336
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
336