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Application of Histone Deacetylase Inhibitors in Renal Interstitial Fibrosis

Ling Nie1, Yong Liu1, Bo Zhang1

  • 1Department of Nephrology, Institute of Nephrology of Chongqing and Kidney Center of PLA, Xinqiao Hospital, Army Medical University (The Third Military Medical University), Chongqing, China.

Kidney Diseases (Basel, Switzerland)
|September 9, 2020
PubMed
Abstract

Insights

Histone deacetylase inhibitors (HDACis) show promise in treating kidney fibrosis by targeting extracellular matrix accumulation. These agents demonstrate antifibrotic effects through various molecular pathways, offering potential therapeutic benefits for chronic kidney diseases.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pharmacology

Background:

  • Renal interstitial fibrosis, marked by extracellular matrix accumulation, is a hallmark of chronic kidney diseases.
  • Aberrant expression of histone deacetylases (HDACs) is implicated in the development and progression of renal fibrosis.

Purpose of the Study:

  • To review the therapeutic potential of histone deacetylase inhibitors (HDACis) as antifibrotic agents for renal fibrosis.
  • To elucidate the molecular mechanisms underlying the antifibrotic effects of HDACis.

Main Methods:

  • Review of recent studies on HDAC inhibitors in animal models of renal fibrosis.
  • Analysis of signaling pathways modulated by HDACis, including TGF-β, EGFR, STAT3, and JNK/Notch2.

Main Results:

  • HDACis have demonstrated significant antifibrotic effects in various preclinical models.
  • These effects are associated with the modulation of key fibrotic signaling pathways.

Conclusions:

  • HDAC inhibitors represent a promising therapeutic strategy for renal fibrosis.
  • Further research and clinical application of HDACis are anticipated to improve outcomes in chronic kidney disease patients.
Keywords:
Histone deacetylasesInhibitorRenal interstitial fibrosisSignaling pathway

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